Toxicological studies

·    Cytotoxicity on cells of human origin
(fibroblasts, melanocytes, keratinocytes, adipocytes, endothelial cells …)

·    Ocular irritation in vitro (neutral red/SIRC or diffusion/agarose gel /L929 according to  OJ)

·    Phototoxicity on Balb/c 3T3 (OECD 432)

·    Skin irritation in reconstructed human epidermis (RhE)

·    Inflammatory potential in reconstructed human epidermis (RhE)

·    Acute toxicity in Mice (OECD 420)(*)

·    Skin irritation / Skin corrosion in Rabbits  (OECD 404)(*)

·    Ocular irritation / Ocular corrosion in Rabbits  (OECD 405)(*)

·    Sensitization in Guinea Pigs (OECD 406)(*)           

·    Pyrogenicity in Rabbits (European Pharmacopoeia)(*)

·    Sub-acute toxicity in Rats (4 weeks) (OECD 407)(*)

·    Sub-chronic toxicity in Rats (12 weeks) (OECD 408)(*)  

·    Carcinogenesis in Rats (OECD 451)(*)

·    Reproductive and developmental toxicity (OECD 415, OECD 416, OECD 414, OECD 421)(*)

Damage to DNA, mutagenicity, genotoxicity

·    Ames test 5 or 6 strains (Salmonella typhimurium, Escherichia coli) (OECD 471)

·    In vitro mammalian chromosome aberration test (human lymphocytes, CHO, V79, TK6)      (OECD 473)

·    COMET assay (DNA degradation, DNA protection) (OECD 489)

·    In vitro mammalian cell gene mutation test (L5178Y, V79, TK6) (OCDE 476, OCDE 490)

·    In vitro mammalian micronucleus test (CHO, TK6) (OCDE 487)

·    Mammalian erythrocyte micronucleus test in Rats (OECD 474)(*)

 

Development of alternative tests for animal testing

 

Screenings and adapted protocols on request

(*)Tests performed in partnership in compliance with Good Laboratory Practice

Pharmaceuticals

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