Biocides and pesticides - Additives for food and feed - Industrial Chemicals

Reminder : Reach is an EU Regulation (Regulation No 1907/2006) applicable since 2007 to secure the manufacturing and use of chemicals in the European industry. This is to identify, assess and control chemical substances manufactured, imported, placed on the European market (substances involved: all the chemicals, including natural substances, such as essential oils, organic substances, such as solvents, and metals such as lead and nickel).

 

Toxicological studies

·    Cytotoxicity on cells of human origin
(fibroblasts, melanocytes, keratinocytes, adipocytes, endothelial cells …)

·    Ocular irritation in vitro (neutral red/SIRC or diffusion/agarose gel /L929 according to  OJ)

·    Phototoxicity on Balb/c 3T3 (OECD 432)

·    Skin irritation in reconstructed human epidermis (RhE)

·    Inflammatory potential in reconstructed human epidermis (RhE)

·    Acute toxicity in Mice (OECD 420)(*)

·    Skin irritation / Skin corrosion in Rabbits  (OECD 404)(*)

·    Ocular irritation / Ocular corrosion in Rabbits  (OECD 405)(*)

·    Sensitization in Guinea Pigs (OECD 406)(*)           

·    Pyrogenicity in Rabbits (European Pharmacopoeia)(*)

·    Sub-acute toxicity in Rats (4 weeks) (OECD 407)(*)

·    Sub-chronic toxicity in Rats (12 weeks) (OECD 408)(*)  

·    Carcinogenesis in Rats (OECD 451)(*)

·    Reproductive and developmental toxicity (OECD 415, OECD 416, OECD 414, OECD 421)(*)

Damage to DNA, mutagenicity, genotoxicity

·    Ames test 5 or 6 strains (Salmonella typhimurium, Escherichia coli) (OECD 471)

·    In vitro mammalian chromosome aberration test (human lymphocytes, CHO, V79, TK6)(OECD 473)

·    COMET assay (DNA degradation, DNA protection) (OECD 489)

·    In vitro mammalian cell gene mutation test (L5178Y, V79, TK6) (OCDE 476, OCDE 490)

·    In vitro mammalian micronucleus test (CHO, TK6) (OCDE 487)

·    Mammalian erythrocyte micronucleus test in Rats (OECD 474)(*)

 

Development of alternative tests for animal testing

 

Screenings and adapted protocols on request

(*)Tests performed in partnership in compliance with Good Laboratory Practice

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Chemical products

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